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The forecast for the match between Mariano Navone and Holger Rune suggests a strong performance by Navone, based on his recent successful matches. Navone showed excellent play in the match against Popyrin and won deservedly. While Rune has not won any titles this season and has been displaying inconsistent results, sometimes losing to even lower-level opponents. Therefore, we do not consider Holger as the clear favorite. It is recommended to consider the handicap for Navone by games (+4.5), given his excellent form.