In the match between Lorenzo Musetti and Giovanni Mpetshi Perricard at the US Open tennis tournament, Musetti, ranked 10th, appears to be the favorite. Despite losing more recent matches, his hard court statistics are better than Perricard's. Two players specializing in clay courts are meeting, but Musetti has shown good performance on hard courts. Perricard is not impressive in the current season. Therefore, I recommend a bet on Musetti to win with a -3.5 game handicap, based on his motivation, experience, and physical form.